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SEZUMINE INJECTION 3
43

SEZUMINE INJECTION

DOH PM 023603


< COMPOSITION >
Each ml Contains:
Acetylcysteine...............100mg


< ACTION >
N-acetyl derivative of L-cysteine, abbreviated as NAC; possesses a strong odor, often described as rotten eggs.
Used orally or parenterally as an antidote for acetaminophen overdose to prevent hepatotoxicity
Used via inhalation as a mucolytic agent to treat and reduce COPD exacerbations.


< INDICATION >
Acetaminophen overdose: Acetylcysteine acts as a hepatoprotective agent by restoring hepatic glutathione, serving as a glutathione substitute, and enhancing the nontoxic sulfate conjugation of acetaminophen.
Mucolytic: Exerts mucolytic action through its free sulfhydryl group which opens up the disulfide bonds in the mucoproteins thus lowering mucous viscosity.

< DOSAGE >
Acetaminophen overdose: Only the  21-hour IV regimens are FDA approved.
As a mucolytic via nebuliser: the adult dose is 3--5 mL acetylcysteine 20% injection, nebulised 3--4 times daily using air (use of concentrated oxygen causes degradation).

< PACKAGE >
3ml×100Amp





ANTITUSSIVES, EXPECTORANTS, ANTIASTHMATICS 1087006