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COBACIDE Tab. (Baktar)

DOH PM 026073

< Composition >
Each tablet contains:
Trimethoprim ...................80mg

< Action >
1. Trimethoprim blocks dihydrofolic acid and reversibly inhibits the required enzyme dihydrofolate reductase to prevent production of tetrhydrofolic acid.
2. Sulfamethoxazole can compete with PABA for incorporation into PGA that blocks the synthesis of folic acid and trimethoprim inhibits the next metabolic step.
3. Body half life is 16 hours. Peak blood level is reached in 1 to 4 hours after taking oral dose. Excreted mainly by kidneys.

< Use >
It is used to treat chronic urinary tract infection due to Klebsiella Enterobacter group, Proteus mirabilis, Vulgaris and morganii. Also it is a treatment of Pneumocystis carinii in children with reduced host defenses, or respiratory, and soft tissue infection. This synergistic drug combination is selected by complex laboratory procedure.

< Dosage >
Adults: 4 tablets daily, 2 tablets every 12 hours.
Children: 1/10 tab/kg/day.

< Package >